How does it effect circadian rhythms ? 
Melatonin produces a substances called arginine vasotocin. This secretion has an inhibiting effect upon cortisol, a stress hormone produced by the adrenal glands. Insomniacs typically tend to have high nighttime levels of the hormone which tends to keep them in an agitated state. inhibition of this hormone promotes sleep and allows time for regeneration.

The metabolic pathway by which melatonin is produced, involves a by product of tryptophan called serotonin. When you consider that tryptophan is the least abundant of the essential amino acids in the normal diet, there is a greater likelihood of a melatonin shortfall because the compound it's produced from, serotonin, would also be reduced.

What about cancer ? 
Melatonin has been described as being oncastatic. A erm that describes its ability to prevent the proliferation of cancer cells. in studies done by hill and Blask at the university of Arizona School of medicine, melatonin inhibited breast cancer cells by as much as 60 to 70%. In another study done by Lissoni et al., at the San Gerardo Hospital in Milan, Italy, melatonin a significantly improved the survival time of patients with brain metastases when compared to those who were treated with steroids and anticonvulsant agents. It appears that the inhibitory effect melatonin has on cancer cell expansion is directly related to its usage. Drs Hill and blask observed that when the patients stopped using melatonin there was an immediate reversal in their conditions.

 What about toxicity ? 
Melatonin, which has been studied for the past two decades, has been administered at doses exceeding 200 mg without any adverse effects. The LD 50 tests done on mice were 1375 mg per Kg of body weight which is an enormous amount when applied to humans. Most studies indicate that melatonin is most efficacious when used at a level of between 1 to 3 mg before bedtime. please note, that any substance can prove to be dangerous at some elevated level including oxygen and water. It is therefore prudent to consult with your doctor or health practitioner, when a health concern arises, before supplementing your diet.

Any contradications ? 
For those adults, over 40, who aren't pregnant, suffering from an auto-immune or endocrine disorder, using anti-depressant drugs, or have reproductive insufficiencies, melatonin could be quite beneficial when used under the guidance of a doctor.

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Rongsheng is equipped with the most advanced test equipments, which can significantly enhance the rationality and accuracy of test. Meanwhile, employees of test department must also abide by the standard operational procedures made for them, thus to examine, monitor and verify the production environment, raw materials and products in different phases, and to conduct data management and analysis for innovation and improvement in the standardized practice.

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